FGF1 and insulin control lipolysis
Jan. 7th, 2022 06:08 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
kostyadоткрыли второй гормон, который регулирует содержание глюкозы в крови . статья в сети опубликована в декабре .на бумаге журнал вышел в январе 2022 Cell Metabolism 2022 v 34 n 1 p 171-183 извините сейчас нет сил написать ссылку в сети .реферат на рус ria.ru science там ссылка
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Date: 2022-01-07 06:52 am (UTC)Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent glucose lowering in diabetic mice that is dose-dependent, but does not lead to hypoglycemia. Chronic pharmacological rFGF1 treatment increases insulin-dependent glucose uptake in skeletal muscle and suppresses hepatic glucose production to achieve whole-body insulin sensitization. The sustained glucose lowering and insulin sensitization attributed to rFGF1 are not accompanied by the side effects of weight gain, liver steatosis and bone loss associated with current insulin sensitizing therapies. Furthermore, we demonstrate that the glucose lowering activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF receptor 1 (FGFR1) signaling. In summary, we have uncovered an unexpected, neomorphic insulin sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for treatment of insulin resistance and type 2 diabetes.
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Date: 2022-01-07 07:07 am (UTC)no subject
Date: 2022-01-07 07:22 am (UTC)